Controlling symptoms can lead to improved quality of life for end of life patients

July 24, 2025

Understanding the symptoms, particularly symptom distress - or the degree to which a symptom bothers a person, is crucial to improved patient care. Intervention at the time of diagnosis is important because patients with stage IIIb or IV lung cancer may approach the end of life quickly.

The study, "Determinants of Quality of Life in Patients Near the End of Life: A Longitudinal Perspective” was conducted by Carla Hermann, PhD, RN, associate professor, University of Louisville School of Nursing, and Stephen Looney, PhD, Medical College of Georgia.

The researchers interviewed 80 patients with either stage IIIb or IV lung cancer who were newly diagnosed or had recurrent lung cancer. The study measured symptom frequency, severity, and distress; functional status; anxiety and depression. Within five months of diagnosis, 40 patients had died. The strongest determinant of QOL was symptom distress, followed by symptom severity, symptom frequency and depression.

“People at the end of life have a wide variety of needs, and healthcare workers need to evaluate patients holistically – focusing not only on physical needs but also on their psycho-social and spiritual needs,” Hermann said. “The end of life can be a time of great personal growth for many, and nurses and other healthcare professionals can help foster that growth.”

The implication of this research for nurses and other healthcare workers is to develop a thorough symptom assessment and to intervene quickly for patients with advanced lung cancer. Nurses and other healthcare professionals have a unique opportunity to make a valuable and lasting impact on patients and their families, Hermann concluded.

The research was funded by a grant from the National Institute of Nursing Research of the National Institutes of Health.

An accompanying podcast titled, "Caring at the End-of-Life: A Time for Personal Growth" is available on the Oncology Nursing Society website.

Related News

University of Louisville School of Nursing's Kentucky Racing Health Services Clinic. A patient is visiting with Dr. Dedra…
Thoroughbred Charities of America 2025 Grantees
February 2, 2026
Community Engagement, Health, Belonging & Access, Student Success, Community Engagement, KRHS, Student Experience
Close-up of the UofL sign near the School of Nursing
Iota Zeta research grants 2025-2026
January 30, 2026
Awards & Recognition, Research & Innovation, Awards, Research, Students
University of Louisville School of Nursing Dean, Dr. Whitney Nash. Nash stands in front of the School of Nursing on HSC…
Cardinal Nurse Quarterly Dean’s Message January 2026
January 23, 2026
Health, Leadership, Quarterly Feature, Academics, Alumni
University of Louisville School of Nursing Director of Community and Campus Engagement, Cynethia Bethel-Hines in front of a…
Cynethia Bethel-Hines and Nursing for Everyone
January 22, 2026
Community Engagement, Health, Belonging & Access, Quarterly Feature, DNP, Community Engagement, Inclusive Excellence, Faculty, Research